Pauline Jackie Duke

Pauline.J.Duke@uth.tmc.edu
Department of Orthodontics
6516 M.D. Anderson, Suite 371
Houston, TX  77030
713-500-4186    

Pauline “Jackie” Duke is a Professor of Orthodontics and Research Coordinator for the Department of Orthodontics at the University of Texas Dental Branch.  Dr. Duke received a BA from Columbia College in SC and an MAT and PhD from Emory University in Atlanta.  She taught high school science for six years after receiving her MAT and prior to entering the PhD Program which she completed in 1978.  From 1978-1980, she was a National Research Council Postdoctoral Fellow in the Biomedical Laboratories at the Johnson Space Center where she studied the effects of in utero and in vitro centrifugation on skeletal development of mouse fetuses and cultured limb buds respectively.  After joining the faculty of the Dental Branch in 1980, these pioneering studies were extended to in vivo effects of excess gravity on mice, including the cephalometric analysis of mice raised under excess gravity.  The culture centrifuge used for limb studies was also used to culture palatal shelves in excess gravity.

Dr. Duke is a member of the University of Texas Graduate School for Biomedical Sciences where she has a tutorial for students interested in Space Biology, and she has provided numerous students from high school to graduate school with research experience in gravitational and space biology.  Dr. Duke has also worked on several spaceflights including Spacelab 3, Cosmos 1886 and 2044 and several simulations, all directed at determining the effect of gravitational changes on skeletal development.

At the Dental Branch, Dr. Duke extended her studies of skeletal development to analyses of cells from humans with hereditary multiple exostoses, and pseudoachondroplasia.  Most recently, her lab has carried out detailed studies of transgenic achondroplasia mice.

As an  investigator on ESA’s Biorack on the International Microgravity laboratory- I mission in 1992, Dr. Duke was instrumental in developing hardware for cell culture in space.  In 1994, she spent the summer as a Visiting Professor at the Space Medicine and Environmental Institute at Nagoya University in Japan.  From here she traveled to Tokyo to carry out clinostat experiments at Tokyo Medical and Dental College.   Her interest in growing cartilage in altered gravity led her to work with JSC on growing cartilage in the rotating bioreactor.  Eventually, this led to a series of tissue engineering experiments which culminated in a recent seed grant to look at the process in more detail. http://www.db.uth.tmc.edu/UTDB_eflash/archive/2007/email_092607.htm

Dr. Duke’s lab has also used the rotating bioreactor to culture embryonic heads in an effort to develop a system to study development of the brachial arches.  Her lab has also studied a calcifying alga, Pleurochrysis carterae.  See Algae and Dentistry: http://www.db.uth.tmc.edu/orthodont/Duke%20NASA/index.html

RECENT PRESENTATIONS:
1. S.J. Chen, and P.J. Duke. 2007. Bioconvection patterns in cultures of a calcifying alga. Presented at the 23rd annual meeting of the American Society for Space and Gravitational Biology. Nov. 2007. Moffett Field, CA.

2.  J Duke,  P Williams, N Horn, J Iverson, V Leonhart, J Kong, and D Montufar-Solis. 2007. Studies of craniofacial development in rotating bioreactors.  International Society of Gravitational Physiology, San Antonio Texas, April 8-13 2007.

3.  P. Jackie Duke,  Paul Williams, Neal Horn, Jeff Iverson, Vicki Leonhart, Jennifer Kong, and Dina Montufar-Solis. 2007. Studies of craniofacial development in rotating bioreactors. Oral presentation at the 24th Annual Houston Conference on Biomedical Engineering Research sponsored by The Houston Society for Engineering in Medicine and Biology, (http://www.hsemb.org/) and held Feb 8th and 9th , 2007, at the Hilton Hotel and Convention Center at the University of Houston.

Selected Student Presentations:

1. S.J. Chen* and J. Duke.  2007.  Development of Embryonic Mouse Heads Embedded in alginate. Hinman Dental Meetings, Memphis, Tenn, Oct 27-29, 2007. 

2.  Machicek* S, S.Murakami and PJ Duke.  2007. Mandible Size and Prognathism of MEK1 Transgenic Achondroplastic Mice. Presented at the IADR meeting New Orleans, La, March March 21-24, 2007.       

3.  Wang, Y*, S Murakami, D Cody and J Duke.  2007. Cranial Base Angle and Length of Cranial Base Bones in Transgenic Achondroplastic Mice.  Presented at the IADR meeting,  New Orleans, La, March 21-24, 2007.       

PUBLICATIONS (most recent):

1. S.J. Chen, and P.J. Duke. 2008. Bioconvection patterns in cultures of a calcifying alga. Gravitation and Space Biology.  In press.
2. P.J. Duke, P. Williams, N. Horn, J. Iverson, V. Leonhart, J. Kong, and  D. Montufar-Solis. 2007.   Studies of craniofacial development in rotating bioreactors.  J. Gravitational Physiology 14: 123-124.
3. Bloom MW, Murakami S, Cody D, Montufar-Solis D, Duke PJ. 2006. Aspects of achondroplasia in the skulls of dwarf transgenic mice:  a cephalometric study. The Anatomical Record Part A 288: 316-322.
4. Detamore MS, Hegde JN, Wagle RR, Almarza AJ, Montufar-Solis D, Duke PJ, Athanasiou KA.  2006.  Cell type and distribution in the porcine temporomandibular joint disc,” Journal of Oral and Maxillofacial Surgery, 64: 243-248.
5. J. Duke, R. Lee, J. English, and J. Teichgraeber. 2006. Countermeasures to the effects of gravity on the skulls of human infants. Gravitational and Space Biology. 19: 137-138
6. Lalani, Z, Duke, Pauline J, Wong, Mark E,  Brey, Eric, Johnston, Carol,  Mikos, Antonios,  Miller, Michael, Montufar-Solis, Dina. 2005. Spatial and temporal localization of FGF-2 and VEGF in healing tooth extraction sockets in a rabbit model. J. Oral Maxillofac Surg 63: 1500-1508.
7. Duke, P.Jackie, W. Callejas, L. Doan, and Mary Marsh. 2005. Phototaxis and aerotaxis in a calcifying alga. Gravitational and Space Biology Bulletin. 18: 115-116.
8. Montufar-Solis, D., Nguyen, H.C., Nguyen H.D, Horn W.N., Cody C.D., and P.J. Duke. 2004. Using cartilage to repair bone: an alternative approach in tissue engineering. Annals of Biomedical Engineering 32: 1-6.

ADDITIONAL WEBSITES:
http://gsbs.gs.uth.tmc.edu/current_faculty.htm
http://www.uth.tmc.edu/ut_general/research_acad_aff/ors/research_innovations/
http://www.db.uth.tmc.edu/orthodont/Duke%20NASA/index.html