There are two primary areas of research in my laboratory. In the first, we are interested in understanding fundamental immunobiological properties that control and regulate mucosal T cell responses, primarily using murine animal models. Active areas of research include studies of immunity in intestinal and oral sites, especially with regard to the events that influence T cell activation and inflammation. These include studies aimed at defining the effects of stimulatory and costimulatory signals in the activation of T cells in response to foreign antigen and viruses.
The second area of research involves studies examining the integrated bi-directional effects of immune-endocrine interactions. In these experiments, the action of neuroendocrine hormones of the hypothalamus-pituitary-thyroid axis is being studied for their potential to regulate the immune response. Similarly, we are interested in determining how the immune system participates in the control of neuroendocrine function and metabolism, particularly with regard to thyroid hormone regulation.
Dr. Klein received a PhD in Infectious Disease Immunology from The Johns Hopkins University in 1980. He did post-doctoral training at the University of Pennsylvania School of Medicine in Philadelphia, PA; the Massachusetts Institute of Technology in Boston, MA; and The Scripps Clinic and Research Foundation in La Jolla, CA. Dr. Klein joined the UT Dental Branch in 2000.
Research in Dr. Klein’s laboratory is funded by the National Institute of Diabetes, Digestion, and Kidney Disease of the National Institutes of Health. Dr. Klein is the Editor-in-Chief of The Open Immunology Journal, and is on the editorial board of Developmental and Comparative Immunology, and Current Immunology Reviews. He is an ad-hoc reviewer for American Journal of Pathology; American Journal of Physiology–Cell Physiology, American Journal of Physiology Lung Cellular and Molecular Physiology, Blood, Cellular Immunology, Chemico-Biological Interactions, European Journal of Endocrinology, Experimental Reviews of Clinical Immunology, Gastroenterology, Gene, Genomics, Gut, Immunology Today, Journal of Endocrinology, Journal of Experimental Medicine, Journal of Infectious Disease, Journal of Immunological Methods, Journal of Leukocyte Biology, Nature Molecular Page Signaling Gateway, Plos One, Proceedings of the National Academy of Science (USA), Protein Expression and Purification, Regional Immunology, Signal Transduction, Science, Urology, and Vision Res.