Cutaneous Reactions To Drugs- From Baer & Harris (from Dr. Montgomery's Seminar)
Describing a skin lesion, Drug Rashes-Methodist Hosp. Houston, DOIA(pictures), University of Iowa-Dermatology (Pictures)
Figure 1-Acneiform eruptions-Caused by bromides, also iodides. Also direct effects of ACTH, glucocorticoids, oral contraceptives, androgenic.
Figure2 , 2a- Bullous eruption- Caused by inorganic arsenical. Other causes iodides, bromides, barbiturates, hydantions and sulfonamides.
Figure 3 Eczematous eruption. Allergic reaction to streptomycin. Also mercurials, neomycin, local anesthetics, antihistamines. DOIA A, B
Figure 4: Toxic epidermal necrolysis-may be fatal. Caused by hydantioin anticonvulsants, also; barbiturates, phenylbutazone, sulfonamides.
Figure 5: Erthema multiforme caused by thiazide diuretic. Also Penicillin, sulfonamides, bromides, idodes, griseofulvin, phenothaleine salicylates. I exaggerated form these can become erythema multiforme bullosum (Stevens-Johnsons Syndrome)- seen with long acting sulfonamides, barbiturates, anticonvulsants.
Figure6: A Erythemia nodosum-like eruption caused by sulfathiazole.B Also produced by bromides, iodides, penicillin, and salicylates.
Figure 7: Exfoliative dermatitis (Exfoliative erythroderma) A, B, -Arsenicals, barbiturates, penicillin, phenothiazines, sulfonamides.
Figure 8: Fixed Eruptions, phenophthalein. Others antipyrine, barbiturates, phenylbutazone, salicylates, tetracycline and sulfonamides.
Figure 9: Fixed eruption on toungue. Phenophthalein. Mucous membranes interact with drug.
Figure 10: Lichen planus like eruption, gold salt. Other drugs thiazide diuretics, chloroquine, quinacrine.
Figure 11: Morbilliform eruption, Bromide. Other drugs: anticonvulsants, barbiturates, streptomycin, novabiocin, penicillin.
Figure 12: Hyperpigmentation of nails: Amodiaquine
Figure 13: Photosensitization, thiazide diuretic. Othes Sulfonamides, sulfonylurease, griseofulvin, tetracyclines, chlorpromazine.
Figure 14: Purpuric eruption, sulfonamide antibiotic. Others Quinidine, penicillin, thazide diuretics, anticoagulants.
Figure 15: Tumor-like (tuberous) lesions. Bromide salt.
Figure 16: Urticarial drug reaction. Many drugs.
Located at: http://faculty.db.uth.tmc.edu/vlewis/cutaneous_reactions_to_drugs.htm
