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M. John Hicks
Professor of Pathology

Education/Training

Institution
Degree
Year Conferred
Field of Study
University of Iowa, Iowa City IA B.S. 1973 Pre-Dentistry
University of Iowa, Iowa City IA D.D.S. 1976 Dentistry
University of Iowa, Iowa City IA M.S. 1978 Pediatric Dentistry
University of Iowa, Iowa City IA Ph.D. 1982 Anatomy
University of Miami, Miami FL Ph.D. 1998 Medicine

Positions:

1993-present Associate Professor, Medical Director of Surgical and Ultrastructural Pathology, Renal Pathology and Oncologic Pathology, Department of Pathology, Baylor College of Medicine, Houston TX
1990-present Adjunct Professor, Department of Pediatric Dentistry, Univ of Texas-Dental Branch , Houston TX
1992-1993 Surgical Pathology Fellow and Chief Fellow, MD Anderson Cancer Ctr, Houston TX
1990-1992 Anatomic Pathology Resident and Chief Resident, Baylor College of Medicine, Houston TX
1989-1990 Anatomic Pathology Resident, School of Medicine, University of Colorado, Denver CO
1988-1989 Transitional Internship, Presbyterian/St. Luke’s Medical Center, Denver CO
1983-86 Associate Professor, Dept of Growth and Development, Univ of Colorado School of Dentistry, Denver, CO
1973-1983 Adjunct Assistant Professor, Div of Cariology, Dows Inst for Dental Research, Univ of Iowa, Iowa City IA
2002-2004

President-Elect, Society for Ultrastructural Pathology

1996-2008 Executive Council Member, Socitey for Ultrastructural Pathology
2000-2003 Practice Committee, Society for Pediatric Pathology
2003-2006 Research Committee, Society for Pediatric Pathology

Editorial Boards:

Sept 2000-present Ultrastructural Pathology, Society for Ultrastructural Pathology
Jan 2000-present Journal of Dentistry for Children, American Society of Dentistry for Children
Jan 2000-present American Journal of Dentistry
May 1997-present & 1985-1986 Pediatric Dentistry, American Academy of Pediatric Dentistry
May 1994 -present Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, Endodontics, Mosby-YearBook Publishers,
Jan 2000-present. American Journal of Dentistry

Honors and Awards:

2003, 2000, 1999, 1998, 1997, 1996, 1995, 1994, 1993 Educational Foundation Research Award, American Academy of Pediatric Dentistry.
March 2002 O’Neal/Spjut Award in Anatomic Pathology for 2001, Department of Pathology, Baylor College of Medicine, Houston.
2001 George W. Teuscher Silver Pen Award for 2001 (inaugural award), American Society of Dentistry for Children, Journalism Award for Best Paper
2002 Harry B. Neustein Award, Society for Pediatric Pathology
1999, 1997, 1995, 1985 Journalism Award, American Society of Dentistry for Children Foundation
1999 Microscopy Society of America Council Award, First Place

Selected Peer-reviewed Publications (in chronological order):

1. Lau CC, Harris CP, Lu XY, Perlaky L, Gogineni S, Chintagumapala M, Hicks J, et al: Frequent amplification and rearrangement of chromosomal bands 6p12-21 and 17p11.2 in osteosarcoma. Genes Chromosomes Cancer 2004;39(1):11-21.
2. Wu J, Borillo J, Glass WF, Hicks J, Ou CN, Lou YH: T-cell epitope of alpha3 chain of type IV collagen induces severe glomerulonephritis. Kidney Int 2003;64(4): 1292-1301.
3. Wang H, Hicks J, Khanbolooki P, Kim SJ, Yan C, Wang Y, Boyd D: Transgenic mice demonstrate novel promoter regions for tissue specific expression of urokinase receptor gene. Am J Pathol 2003;163(2):453-64.
4. Hicks J, Garcia-Godoy F, Flaitz C: Biologic factors I dental caries: role of saliva and dental plaque in the dynamic process of demineralization and remineralization (part 1). J Clin Pediatr Dent 2003;28(1):47-52.
5. Flaitz C, Allen C, Neville B, Hicks J: Juvenile xanthogranuloma of the oral cavity in children: a clinicopathologic study. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, Endodontics 2002;94(3):345-52.
6. Hicks J, Flaitz C: Progressive transformation of germinal centers: review of histopathologic and clinical features. International Journal of Otorhinolaryngology 2002;65(3):195-202.
7. Flaitz CM, Nichols CM, Walling DM, Hicks MJ: Plasmablastic lymphoma: an HIV-associated entity with primary oral manifestations. Oral Oncology 2002;38(1):95-102.
8. Dickinson DP, Thiesse M, Hicks J: Expression of type 2 cystatin genes CST1-CST5 in adult human tissues and developing submandibular glands. DNA Cell Biol 2002 Jan;21(1):47-65.
9. Holsinger FC, Weeks BH, Hicks MJ, Friedman EM: Contemporary concepts in the management of pediatric rhabdomyosarcoma. Current Opinion in Otolaryngology & Head and Neck Surgery 2002;10:91-96.
10. Flaitz CM, Hicks MJ: Mucocele and ranula. http://www.emedicine.com/emerg/topic 169.htm, eMedicine Journal, 2002;3(3):1-10.
11. Hicks J, Flaitz C: Rhabdomyosarcoma of the head and neck in children. Oral Oncol 2002;38(5): 450-459, August.
12. Hicks J: Congenital self-healing Langerhans cell histiocytosis: complimentary role of immunocytochemical and ultrastructural evaluation. Pathology Case Reviews 2002;7(5):209-17, August-September
13. Wu J, Hicks J, Ou C, Singleton D, Borillo J, Lou YH: Glomerulonephritis induced by recombinant collagen IV alpha 3 chain noncollagen domain 1 is not associated with glomerular basement membrane antibody: a potential T cell-mediated mechanism. J Immunol 2001;167(4):2388-95.
14. Flaitz CM, Hicks MJ: Pulp Polyp. http://www.emedicine.com/emerg/topic 169.htm eMedicine Journal 2001;2(9):1-8.
15. Stal S, Tjelmeland K, Hicks J, Bhatia N, Eppley B, Hollier L: Compartmentalized bone regeneration of cranial defects with biodegradable barriers: an animal model. J Craniofac Surg 2001;12(1):41-7.
16. Flaitz CM, Wullbrandt B, Sexton J, Bourdon T, Hicks J: Prevalence of orodental findings in HIV-infected Romanian children. Pediatr Dent 2001;23(1):44-50.
17. Hicks J, Wild T, Flaitz C, Seybold S: Fluoride varnishes and caries development in primary tooth enamel: an in vitro study. ASDC J Dent Child 2001;68(5&6):304-10, Sept-Dec.
18. Agostini FG, Flaitz CM, Hicks MJ: A retrospective survey of dental emergencies in a university- based pediatric dental clinic. ASDC J Dent Child 2001;68(5&6):316-21.
19. Flaitz CM, Hicks J: Delayed tooth eruption associated with ameloblastic fibro-odontoma. Pediatr Dent 2001;23(3):253-4.
20. Hicks MJ, Flaitz CM: External root resorption of a primary molar: “incidental” histopathologic finding of clinical significance. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2001;92(1):4-8.
21. Hicks MJ, Parkins FM, Flaitz CM: Kinetic cavity preparation effects on secondary caries formation around resin restorations: a polarized light microscopic in vitro evaluation. ASDC J Dent Child 2001;68(2):115-21,80,142.
22. Westerman G, Hicks J, Flaitz C: Argon laser curing of fluoride releasing pit and fissure sealant: in vitro caries development. ASDC J Dent Child 2001;67(6):385-90,374.
23. Hicks J, Garcia-Godoy F, Milano M, Flaitz CM: Compomer materials and secondary caries formation. Am J Dent 2001;13(5):231-4.
24. Ceballos L, Toledano M, OsorioR, Garcia-Godoy F, Flaitz C, Hicks J: Er-YAG laser pretreatment effect on in vitro secondary caries formation around composite restorations. Am J Dent 2001;14(1):46-9.
25. Hicks MJ, Flaitz CM: Oral mucosal melanoma: epidemiology and pathobiology. Oral Oncology 2000;36:152-69.
26. Hicks J, Flaitz C: Mucoepidermoid carcinoma of salivary glands in children and adolescents: assessment of proliferation markers. Oral Oncol 2000;36(5):454-60.
27. Kozinetz CA, Carter AB, Simon C, Hicks MJ, Rossmann SN, Flaitz CM, Cron SG, Kline MW: Oral manifestations of pediatric vertical HIV infection. AIDS Patient Care STDS. 2000;14:89-94.
28. Hicks MJ, Flaitz CM, Carter AB, Cron SG, Rossmann SN, Simon CL, Demmler GJ, Kline MW: Dental caries in HIV-infected children: a longitudinal study. Pediatr Dent 2000;22(5):359-64.
29. Hicks MJ, Flaitz CM: Resin-modified glass ionomer restorations and in vitro secondary caries formation in coronal enamel. Quintessence International, 2000;31(8):570-8.
30. Hicks MJ, Westerman GH, Flaitz CM, Powell GL: Surface topography and enamel-resin interface of pit and fissure sealants following visible light and argon laser polymerization: an in vitro study. ASDC J Dent Child 2000;67:169-75.
31. Hicks MJ, Flaitz CM: Enamel caries formation and lesion progression with a fluoride dentifrice and a calcium-phosphate containing fluoride dentrifrice: a polarized light microscopic study. ASDC J Dent Child 2000;67:21-8.
32. Hicks MJ, Flaitz CM, Garcia-Godoy F: Fluoride-releasing sealant and caries-like enamel lesion formation in vitro. J Clin Pediatr Dent. 2000;24(3):215-19.
33. Hicks MJ, Flaitz CM: Occlusal caries formation in vitro: comparison of resin-modified glass ionomer with fluoride-releasing sealant. J Clin Pediatr Dent 2000;24(4):309-14.
34. Simon C, Hicks MJ (shares first co-authorship with C Simon), Nemechek AJ, O’Malley Jr BW, Goepfert H, Flaitz CM, Boyd D: PD08059, an inhibitor of ERK1 activation, attentuates the in vivo invasiveness of head and neck squamous cell carcinoma. Br J Cancer 1999;80(9):1412-9.
35. Flaitz CM, Hicks MJ: Oral candidiasis in children with immune suppression: clinical appearance and therapeutic considerations. ASDC J Dent Child 1999;66(3):161-6,154.
36. Westerman GH, Hicks MJ, Flaitz CM, Blankenau RJ, Powell GL: Combined effects of acidulated phosphate fluoride and argon laser on sound root surface morphology; an in vitro scanning electron microscopic study. J Clin Laser Med Surg 1999;17:63-8
37. Flaitz C.M., Hicks MJ: Molecular piracy: the viral link to carcinogenesis. Oral Oncol 1998;34(6):448 53.
38. Simon C, Nemechek AJ, Boyd D, O’Malley BW Jr, Goepfert H, Flaitz CM, Hicks MJ: An orthotopic floor-o-mouth cancer model allows quantification of tumor invasion. Laryngoscope 1998;108(11 Pt1):1686-91.
39. Garcia-Godoy F, Flaitz CM, Hicks J: Secondary caries adjacent to amalgam restorations lined with a fluoridated dentin desensitizer. Am J Dent 1998;11(6):254-8.
40. Stal S, Hicks MJ: Classic and occult submucous cleft palates: a histopathologic analysis. Cleft Palate Craniofac J 1998;35(4):351-8.
41. Khadaroo RG, Walton RJ, Ramsay JA, Hicks MJ, Archibald SD: Mucoepidermoid carcinoma of the parotid gland: a rare presentation in a young child. J Pediatr Surg 1998;33(6):893-5.
42. Hicks MJ, Carter AB, Rossmann SN, Demmler GJ, Simon CL, Cron SG, Flaitz CM, Shearer WT, Kline MW: Detection of fungal organisms in saliva from HIV-infected children: a preliminary cytologic analysis. Pediatric Dentistry 1998;20(3):162-8.
43. Flaitz CM, Hicks MJ, Carter AB, Rossmann SN, Demmler GJ, Simon CL, Cron SG, Shearer WT, Kline MW: Saliva collection technique for cytologic, microbiologic and viral evaluation in pediatric HIV infection. ASDC J Dent Child 1998;65(5);318-24,355.
44. Hicks MJ, Flaitz CM: Caries formation in vitro around a fluoride-releasing pit and fissure sealant in primary teeth. ASDC J Dent Child 1998;65(3):161-8
45. Hicks MJ, Flaitz CM, Garcia-Godoy F: Root surface caries formation: Effect in vitro APF Treatment. J Am Dent Assoc 1998;129(4):449-53.
46. Rossmann S, Wilson P, Hicks J, Carter B, Crons S, Flaitz C, Demmler G, Shearer W, Kline M: Lautropic mirabilis is associated with HIV in the oral cavities of children. J Clin Microbiol 1998;36(6):1756-60.
47. Jacob LS, Flaitz CM, Nichols CM, Hicks MJ: Role of dentinal carious lesions in the pathogenesis of oral candidiasis in HIV infection. J Am Dent Assoc. 1998;129(2):187-94.
48. Westerman GH, Hicks MJ, Flaitz CM, Blankenau RL, Powell GL: Argon laser irradiation effects on sound root surfaces: in vitro scanning electron microscopic observations. J Clin Laser Med Surg. 1998(2);16:111-5.
49. Hicks, M.J., Flaitz, C.M., Cohen, P.R.: Perioral and Cutaneous Umbilicated Papular Lesions in Acquired Immunodeficiency Syndrome. Oral Surgery, Oral Medicine, Oral Pathology, Endodontics. 1997:83:189-91.
50. Flaitz C.M., Jin Y.T., Hicks M.J., Nichols C.M., Wang Y-W, Su I-J: Kaposi’s sarcoma-associated Herpesvirus-like DNA Sequences (KSHV/HHV-8) in oral AIDS-Kaposi’s Sarcoma. Oral Surgery, Oral Medicine, Oral Pathology, Endodontics 1997;83:259-64.

Research Support

1. Molecular Classification of Osteosarcoma, NIH-NCI Director’s Challenge Grant, Principal Investigator (Ching Lau), February 2001 to February 2006 ($5.2 million). 10% effort.
2. Oral Manifestations of Pediatric HIV Infection, NIH-NIDR, (1-RO1-DE11363), September 1994 to September 1999, Co-Investigator. (Dr. Mark Kline, Principal Investigator, $1.2 million). 10% effort.
3. The Effects of Normal Aging Process on the Larynx. Isla Carroll Turner Friendship Trust. July 1995 to July 2000, Co-Investigator. (Dr. C. Richard Stasney, co-investigator, $160,000). 20% effort
4. Design for a Mouse Model of Langerhans Cell Histiocytosis. Histiocyte Association of America. Co-investigtor (Dr. Kenneth McClain, Co-Investigator, $50,000). June 2001. 5% effort Consultant (Collaborator)
1. Molecular Basis of Rothmund-Thomson Syndrome, Principal Investigator: Lisa Wang, NIH-NCI KO8 Grant and Doris Duke Charitable Foundation Clinical Scientist Development Award, February 2002-February 2007 ($500,000). 5% effort
2. Urokinase Receptor Regulation in Transgenic Mice, Principal Investigator: Douglas Boyd, NIH, 2001 ($1.2 million). 5% effort
3. Role of P and E-selectin in the Development of Vasculitis, Investigator: Daniel Bullard, Arthritis Foundation of America, April 2000 ($50,000).
4. Role of Selectins in the Development of Vasculitis, Investigator: Daniel Bullard, Arthritis Foundation of America, January 1999 ($50,000).

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